Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
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pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of CYP3A4 inducers could lower sufentanil concentrations and efficacy, possibly precipitating withdrawal syndrome in sufferers who have formulated physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers might boost sufentanil plasma concentration.
Contraindicated (one)pentobarbital will lower the extent or effect of doravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Observe Closely (two)pentobarbital will lessen the level or effect of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. If coadministration with a CYP3A4 inducer is essential, consider raising oliceridine dose right until steady drug effects are obtained; keep an eye on for indications of opioid withdrawal.
Contraindicated (1)pentobarbital will reduce the extent or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or effect of siponimod by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of siponimod with a drug that causes average CYP2C9 additionally a average or sturdy CYP3A4 inducer isn't advisable.
pentobarbital will lessen the extent or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or effect of conjugated estrogens, vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will lower the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.
pentobarbital will lower the level or effect of voriconazole by affecting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Unknown.
pentobarbital and daridorexant each boost sedation. Modify Therapy/Watch Intently. Coadministration increases risk of CNS melancholy, which can lead to additive impairment of psychomotor functionality and bring about daytime impairment.
pentobarbital will reduce the extent or effect of venetoclax by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or effect of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Strong or moderate CYP3A4 inducers might maximize level of diazepam elimination; thus, efficacy of diazepam could be decreased.
pentobarbital and olopatadine intranasal equally enhance sedation. Steer clear of or Use Alternate Drug. Coadministration improves threat of CNS despair, which can lead to additive impairment of psychomotor effectiveness and cause daytime impairment.
pentobarbital will reduce the level or effect of capivasertib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Robust or moderate CYP3A inducers decrease capivasertib publicity, which get more info may minimize efficacy.